Impact of Common Modifications on the Antigenic Profile and Glycosylation of Membrane-Expressed HIV-1 Envelope Glycoprotein.
T. Tong, A. D'Addabbo, J. Xu, H. Chawla, A. Nguyen, P. Ochoa, M. Crispin, J. M. Binley
This study evaluates how stabilizing mutations in HIV-1 Env affect trimer stability, antigenicity, and glycosylation when expressed on membrane-expressed VLPs, finding some mutations reduce neutralizing antibody binding and alter glycan processing.
bioRxiv · Jun 2, 2023 · PreprintImmunology