Author

J. M. Binley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. D'Addabbo· 3 shared M. Crispin· 3 shared A. Thomas· 2 shared E. Crooks· 2 shared J. Allen· 2 shared J. Xu· 2 shared K. Osawa· 2 shared T. Tong· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

A. D'Addabbo

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3 papers

Recent·Most cited

Impact of Glycan Depletion, Glycan Debranching and Increased Glycan Charge on HIV-1 Neutralization Sensitivity and Immunogenicity

A. D'Addabbo, T. Tong, E. Crooks, K. Osawa, J. Xu, A. Thomas, J. Allen, M. Crispin, J. M. Binley

This study evaluates glycoengineered HIV-1 trimers to enhance bNAb recognition, finding that B4GalT1+ST6GalT1 modifications increase antibody titers in infected donors but reduce vaccine-induced neutralizing antibodies.

Glycobiology · Aug 8, 2024Peer-reviewedImmunology

Impact of Common Modifications on the Antigenic Profile and Glycosylation of Membrane-Expressed HIV-1 Envelope Glycoprotein.

T. Tong, A. D'Addabbo, J. Xu, H. Chawla, A. Nguyen, P. Ochoa, M. Crispin, J. M. Binley

This study evaluates how stabilizing mutations in HIV-1 Env affect trimer stability, antigenicity, and glycosylation when expressed on membrane-expressed VLPs, finding some mutations reduce neutralizing antibody binding and alter glycan processing.

bioRxiv · Jun 2, 2023 · PreprintImmunology

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

J. M. Binley, E. Crooks, F. Almanza, A. D'Addabbo, E. Duggan, J. Zhang, K. Wagh, H. Mou, J. Allen, A. Thomas, K. Osawa, B. Korber, Y. Tsybovsky, E. Cale, J. Nolan, , L. Verkoczy

This paper engineers HIV-1 envelope trimers with enhanced V2 and fusion peptide neutralization sensitivity for vaccine development.

bioRxiv · Jul 20, 2021Immunology