Author

P. Pymm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

W.-H. Tham· 2 shared A. Adair· 1 shared A. G. Brooks· 1 shared A. W. Lo· 1 shared D. Drew· 1 shared F. J. Rossello· 1 shared G. Nie· 1 shared G. Sun· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

W.-H. Tham

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Author profile →

3 papers

Recent·Most cited

Prediction of KIR3DL1/Human Leukocyte Antigen binding

M. Maiers, Y. Louzoun, P. Pymm, J. P. Vivian, J. Rossjohn, A. G. Brooks, P. M. Saunders

The paper builds a machine learning model to predict KIR3DL1 binding to HLA class I allotypes, showing that binding is influenced by multiple non-additive regions beyond the classical Bw4 motif.

bioRxiv · May 3, 2024Immunology

An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts

J. Chen, J. A. Neil, J. P. Tan, R. Rudraraju, M. Mohenska, Y. B. Sun, G. Sun, Y. Zhou, Y. Li, D. Drew, P. Pymm, W.-H. Tham, F. J. Rossello, G. Nie, X. Liu, , J. M. Polo

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

bioRxiv · Oct 27, 2021 · PreprintCell Biology

Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p

M. H. Dietrich, L.-J. Chan, A. Adair, S. Keremane, P. Pymm, A. W. Lo, Y.-C. Cao, W.-H. Tham

The paper presents the first crystal structure of Pf12p, a 6-cysteine protein from Plasmodium falciparum, and describes nanobodies that target distinct epitopes on the protein.

bioRxiv · Dec 12, 2020Microbiology