W.-H. Tham

Potent AMA1-specific human monoclonal antibody against P. vivax Pre-erythrocytic and Blood Stages

The paper isolates a human monoclonal antibody that targets Plasmodium vivax AMA1, blocking both pre-erythrocytic and blood stage infections.

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

This study tracks antibody kinetics against Plasmodium vivax antigens in individuals from a low-transmission region, showing long-lived IgG responses and IgM variability.

Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p

The paper presents the first crystal structure of Pf12p, a 6-cysteine protein from Plasmodium falciparum, and describes nanobodies that target distinct epitopes on the protein.

A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens in a multiplexed bead-based assay using Luminex(R) technology (Bio-Plex(R)200 or MAGPIX(R))

This study compares non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens using Luminex technology across different instruments, finding strong correlations but noting higher protein requirements for magnetic beads.

Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b

The paper isolates and characterizes human monoclonal antibodies against PvRBP2b that block its function in P. vivax invasion.

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

The paper identifies and validates a panel of 8 P. vivax proteins whose IgG antibody responses can detect recent exposure to P. vivax infections within the prior 9 months with 80% sensitivity and specificity.