Coarse-Grained Modelling of DNA Plectoneme Pinning in the Presence of Base-Pair Mismatches
P. R. Desai, S. Brahmachari, J. F. Marko, S. Das, K. C. Neuman
This study uses coarse-grained MD simulations to show that DNA plectoneme pinning at mismatches is deterministic under high force and salt, but probabilistic under physiological conditions, with pinning probability increasing with mismatch size.
bioRxiv · Dec 20, 2019Biophysics