Synthetic single domain antibodies for the conformational trapping of membrane proteins
I. Zimmermann, P. Egloff, C. Hutter, P. Stohler, N. Bocquet, M. Hug, M. Siegrist, L. Svacha, J. Gera, S. Gmuer, P. Spies, D. Gygax, E. R. Geertsma, R. J. P. Dawson, M. A. Seeger
This study develops a synthetic nanobody platform to generate conformation-specific binders for membrane proteins, overcoming limitations of traditional immunization methods.
bioRxiv · Jul 26, 2017Bioengineering