Author

P. Egloff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

I. Zimmermann· 5 shared M. A. Seeger· 5 shared C. A. J. Hutter· 3 shared G. Meier· 2 shared I. Gonda· 2 shared J. D. Walter· 2 shared L. M. Hürlimann· 2 shared M. Sorgenfrei· 2 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersBiochemistry

I. Zimmermann

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies

M. Botte, D. Ni, S. Schenck, I. Zimmermann, M. Chami, N. Bocquet, P. Egloff, D. Bucher, M. Trabuco, R. K. Y. Cheng, J. D. Brunner, M. A. Seeger, H. Stahlberg, M. Hennig

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

bioRxiv · Mar 23, 2021 · PreprintBiochemistry

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance

J. D. Walter, C. A. J. Hutter, A. A. Garaeva, M. Scherer, I. Zimmermann, M. Wyss, J. Rheinberger, Y. Ruedin, J. C. Earp, P. Egloff, M. Sorgenfrei, L. Hürlimann, I. Gonda, G. Meier, S. Remm, , M. A. Seeger

bioRxiv · Nov 10, 2020Biochemistry

Sybodies targeting the SARS-CoV-2 receptor-binding domain

J. D. Walter, C. A. J. Hutter, I. Zimmermann, M. Wyss, P. Egloff, M. Sorgenfrei, L. M. Hürlimann, I. Gonda, G. Meier, S. Remm, S. Thavarasah, P. Plattet, M. A. Seeger

This paper reports the rapid in vitro selection of sybodies targeting the SARS-CoV-2 receptor-binding domain, identifying potent inhibitors with ACE2 blocking activity and potential for therapeutic development.

bioRxiv · Apr 16, 2020 · PreprintBiochemistry

The extracellular gate shapes the energy profile of an ABC exporter

C. A. J. Hutter, M. H. Timachi, L. M. Hürlimann, I. Zimmermann, P. Egloff, H. Göddeke, S. Kucher, S. Stefanic, M. Karttunen, L. V. Schäfer, E. Bordignon, M. A. Seeger

This study uses a synthetic antibody to determine the structure and mechanism of an ABC exporter's extracellular gate, showing its role in ATPase activity and transport.

bioRxiv · Sep 18, 2018Biochemistry

Synthetic single domain antibodies for the conformational trapping of membrane proteins

I. Zimmermann, P. Egloff, C. Hutter, P. Stohler, N. Bocquet, M. Hug, M. Siegrist, L. Svacha, J. Gera, S. Gmuer, P. Spies, D. Gygax, E. R. Geertsma, R. J. P. Dawson, M. A. Seeger

This study develops a synthetic nanobody platform to generate conformation-specific binders for membrane proteins, overcoming limitations of traditional immunization methods.

bioRxiv · Jul 26, 2017Bioengineering