Author

J. Gera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. N. Nishimura· 3 shared A. Benavides-Serrato· 2 shared B. Holmes· 2 shared G. Jordaan· 2 shared J. E. Hansen· 2 shared A. B. Baldridge· 1 shared A. Shirali· 1 shared B. J. Cuffari· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

R. N. Nishimura

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

J. Gera, M. Agard, H. Nave, A. B. Baldridge, F. Sajadi, L. Thorat, T. H. McKim, S. Kondo, D. Nassel, M. H. Omar, J.-P. V. Paluzzi, M. Zandawala

This paper characterizes the ITP signaling system in Drosophila, identifying ITPa as an anti-diuretic hormone that acts via the Gyc76C receptor to modulate osmoregulation and metabolic homeostasis.

bioRxiv · Feb 7, 2024Physiology

Cellular protection from H2O2 toxicity by Fv-Hsp70 and mutants of Fv-Hsp70. Protection via catalase and gamma-glutamyl cysteine synthase.

C. Hino, G. Chan, G. Jordaan, S. S. Chang, J. Saunders, M. T. Bashir, J. E. Hansen, J. Gera, R. H. Weisbart, R. N. Nishimura

This study shows Fv-Hsp70 and its mutants protect SH-SY5Y cells from H2O2 toxicity through a protein-binding domain, and this protection involves catalase and gamma-glutamylcysteine synthase.

bioRxiv · Feb 22, 2023 · PreprintCell Biology

cGAS-activating lupus autoantibody for cancer immunotherapy

X. Chen, X. Tang, B. J. Cuffari, C. Tang, X. Gao, P. W. Noble, M. R. Young, O. M. Turk, A. Shirali, J. Gera, R. N. Nishimura, J. Zhou, J. E. Hansen

This study shows a lupus anti-DNA autoantibody activates cGAS and improves survival in glioblastoma models by enhancing CD8+ T cell infiltration.

bioRxiv · Feb 11, 2023 · PreprintImmunology

Targeting the mTORC2 signaling complex in B cell malignancies.

W. Liao, G. Jordaan, A. Benavides-Serrato, B. Holmes, J. Gera, S. Sharma

This study identifies novel inhibitors that disrupt the mTORC2 complex and induce apoptosis in chronic lymphocytic leukemia cells more effectively than existing treatments.

bioRxiv · Mar 5, 2019 · PreprintCancer Biology

Synthetic single domain antibodies for the conformational trapping of membrane proteins

I. Zimmermann, P. Egloff, C. Hutter, P. Stohler, N. Bocquet, M. Hug, M. Siegrist, L. Svacha, J. Gera, S. Gmuer, P. Spies, D. Gygax, E. R. Geertsma, R. J. P. Dawson, M. A. Seeger

This study develops a synthetic nanobody platform to generate conformation-specific binders for membrane proteins, overcoming limitations of traditional immunization methods.

bioRxiv · Jul 26, 2017Bioengineering

mTORC2/AKT/HSF1/HuR Constitute A Feed-Forward Loop Regulating Rictor Expression And Tumor Growth In Glioblastoma

B. Holmes, A. Benavides-Serrato, R. S. Freeman, K. A. Landon, T. Bashir, R. N. Nishimura, J. Gera

This study identifies a feed-forward loop involving mTORC2/AKT/HSF1/HuR that regulates Rictor expression and promotes glioblastoma growth.

bioRxiv · May 19, 2017Cancer Biology