Author

N. Bocquet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Organism:human· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Bucher· 2 shared H. Stahlberg· 2 shared I. Zimmermann· 2 shared M. A. Seeger· 2 shared M. Botte· 2 shared M. Chami· 2 shared M. Hennig· 2 shared P. Egloff· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

D. Bucher

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies

M. Botte, D. Ni, S. Schenck, I. Zimmermann, M. Chami, N. Bocquet, P. Egloff, D. Bucher, M. Trabuco, R. K. Y. Cheng, J. D. Brunner, M. A. Seeger, H. Stahlberg, M. Hennig

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

bioRxiv · Mar 23, 2021 · PreprintBiochemistry

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

M. Botte, A. K. C. Ulrich, R. Adaixo, D. Gnutt, A. Brockmann, D. Bucher, M. Chami, N. Bocquet, U. Ebbinghaus-Kintscher, V. Puetter, A. Becker, U. Egner, H. Stahlberg, M. Hennig, S. J. Holton

This paper reports the cryo-EM structure of hTRPV4 in an open conformation induced by 4-PDD agonist, revealing molecular mechanisms of activation and providing a template for inhibitor design.

bioRxiv · Oct 13, 2020 · PreprintMolecular Biology

Synthetic single domain antibodies for the conformational trapping of membrane proteins

I. Zimmermann, P. Egloff, C. Hutter, P. Stohler, N. Bocquet, M. Hug, M. Siegrist, L. Svacha, J. Gera, S. Gmuer, P. Spies, D. Gygax, E. R. Geertsma, R. J. P. Dawson, M. A. Seeger

This study develops a synthetic nanobody platform to generate conformation-specific binders for membrane proteins, overcoming limitations of traditional immunization methods.

bioRxiv · Jul 26, 2017Bioengineering