Genetically-modified X. laevisindicate distinct roles for prominin-1 and photoreceptor cadherin in outer segment morphogenesis and retinal dystrophy
B. J. Carr, P. Stanar, O. L. Moritz
This study uses CRISPR/Cas9 to generate X. laevis mutants to investigate the roles of prom1 and cdhr1 in photoreceptor outer segment morphogenesis and retinal degeneration, finding they are critical for higher-order disc organization rather than disc formation.
bioRxiv · Aug 23, 2020Cell Biology