Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules
J. Osten, M. Mohebbi, P. Uta, F. Matinmehr, T. Wang, T. Kraft, M. Amrute-Nayak, T. Scholz
The paper shows that MLC1sa in soleus myosin slows actin gliding compared to MLC1sb/v in ventricular myosin, likely due to increased actin affinity and reduced dissociation rate.
bioRxiv · Mar 8, 2022Physiology