M. Amrute-Nayak

Sorafenib induces muscle wasting by disrupting the activity of distinct chromatin regulators

This study shows Sorafenib causes muscle wasting by disrupting chromatin regulators, leading to transcriptional changes and impaired muscle function.

Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemo-mechanical properties despite the same myosin heavy chain isoform.

This study compares the chemo-mechanical properties of cardiac ventricular and slow skeletal myosins with the same heavy chain isoform, finding distinct kinetic and mechanical behaviors.

Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules

The paper shows that MLC1sa in soleus myosin slows actin gliding compared to MLC1sb/v in ventricular myosin, likely due to increased actin affinity and reduced dissociation rate.

Single-molecule analysis reveals the role of regulatory light chains in fine-tuning skeletal myosin-II function

The paper investigates how regulatory light chains (RLCs) influence the functional diversity of myosin-II isoforms by swapping RLCs with different myosin heavy chains and measuring changes in actin filament sliding velocity.