Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution
J. R. Blundell, G. Y. P. Poon, A. Vedi, E. Laurenti, M. A. Sanders, P. Valk
This study uses single-cell DNA sequencing to analyze preleukemic hematopoietic stem cells and finds pervasive positive selection throughout preleukemic evolution, with selective advantages ranging from 9%-24% per year.
bioRxiv · Dec 15, 2023Cancer Biology