Author

J. R. Blundell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. S. Fisher· 2 shared G. Y. P. Poon· 2 shared A. Vedi· 1 shared C. J. Watson· 1 shared D. Francois· 1 shared E. Laurenti· 1 shared G. J. Sherlock· 1 shared I. Ayestaran· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersEvolutionary Biology

D. S. Fisher

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Author profile →

4 papers

Recent·Most cited

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

J. R. Blundell, G. Y. P. Poon, A. Vedi, E. Laurenti, M. A. Sanders, P. Valk

This study uses single-cell DNA sequencing to analyze preleukemic hematopoietic stem cells and finds pervasive positive selection throughout preleukemic evolution, with selective advantages ranging from 9%-24% per year.

bioRxiv · Dec 15, 2023Cancer Biology

Dynamics of TCRβ repertoires from serial sampling of healthy individuals

J. R. Blundell, I. Ayestaran

This study develops a statistical framework to identify TCR clonotypes under immune selection in time series data and finds that dynamic clusters of clonotypes suggest shared immunogenic stimuli despite diverse sequence features.

bioRxiv · May 11, 2022 · PreprintImmunology

Synonymous mutations reveal genome-wide driver mutation rates in healthy tissues

G. Y. P. Poon, C. J. Watson, D. S. Fisher, J. R. Blundell

The paper estimates genome-wide driver mutation rates in healthy tissues using synonymous passenger mutations and finds many driver mutations occur outside of known cancer genes in blood but not in oesophagus.

bioRxiv · Oct 8, 2020Evolutionary Biology

The dynamics of adaptive genetic diversity during the early stages of clonal evolution

J. R. Blundell, K. Schwartz, D. Francois, D. S. Fisher, G. J. Sherlock, S. F. Levy

This study investigates genetic diversity dynamics in clonally evolving populations, finding predictable early increases followed by a diversity crash due to highly-fit double mutants.

bioRxiv · Jul 31, 2017Evolutionary Biology