Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: II. Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic Pathology in HIP Rats
L. Wu, P. Velander, A. M. Brown, Y. Wang, D. Liu, D. R. Bevan, S. Zhang, B. Xu
This study identifies rosmarinic acid as a potent inhibitor of amylin aggregation and shows its efficacy in reducing amyloid deposits and mitigating diabetic pathology in HIP rats.
bioRxiv · Dec 13, 2020Pharmacology & Toxicology