A. M. Brown

Mechanistic insights into transport models of the sphingolipid transport protein, Spinster homolog 2 (Spns2), using MD simulations

This study uses MD simulations to investigate the structural mechanisms of S1P transport by Spns2, identifying key residues and a rocker-switch model for potential inhibitor development.

Site-specific sulfations regulate the physicochemical properties of papillomavirus-heparan sulfate interactions for entry

The paper investigates how specific sulfation patterns on heparan sulfate affect HPV16 binding and structural activation, revealing their role in virus entry.

From goal to outcome: analyzing the progression of biomedical sciences PhD careers in a longitudinal study using an expanded taxonomy

This study tracks biomedical sciences PhD careers over ten years, finding most students change career goals, fewer pursue postdocs, and first non-training positions predict long-term careers.

Optimizing Short-format Training: an International Consensus on Effective, Inclusive, and Career-spanning Professional Development in the Life Sciences and Beyond

This paper presents 14 recommendations to improve short-format training in STEMM fields through a framework called the Bicycle Principles, aiming to make training more effective, inclusive, and career-spanning.

Widespread exposure to SARS-CoV-2 in wildlife communities

The paper documents SARS-CoV-2 exposure in six wildlife species and finds higher seroprevalence in areas with high human activity, suggesting human-to-animal transmission events.

Phylogenetic and Ecological Trends in Specialization: Disentangling the Drivers of Ectoparasite Host Specificity

This study investigates factors driving host specificity in bat flies, finding that ecological competition better predicts specialization than coevolution.

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

This paper identifies a mutation in the E2 glycoprotein of Mayaro virus that enhances transmission in Aedes aegypti but reduces replication in human cells, suggesting a trade-off in host adaptation.

Insight into Cross-Amyloid Interactions and Morphologies: Molecular Dynamics Simulations of Model Peptide Fragments of Amyloid-β (Aβ16-22) and Islet Amyloid Polypeptide (IAPP20-29)

This study uses molecular dynamics simulations to investigate cross-amyloid interactions between Aβ16-22 and IAPP20-29, revealing structural morphologies and potential cytotoxic mechanisms.

A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

The paper identifies a selective sweep in the Spike gene of SARS-CoV-2 that enhanced human adaptation by improving binding to human ACE2 and replication in human cells.

Older mothers produce offspring with longer telomeres: a longitudinal within-parent analysis

The paper shows that older mothers produce offspring with longer telomeres, suggesting a transgenerational effect of parental age on telomere length in wild birds.

Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: II. Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic Pathology in HIP Rats

This study identifies rosmarinic acid as a potent inhibitor of amylin aggregation and shows its efficacy in reducing amyloid deposits and mitigating diabetic pathology in HIP rats.

Measuring effects of trainee professional development on research productivity: A cross-institutional meta-analysis

This study analyzes the impact of professional development programs on doctoral students' research productivity and time to degree across ten institutions, finding no negative effects and some positive correlations.

Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides

This study identifies critical residues in a Dab2-derived peptide that bind sulfatides and inhibit platelet aggregation.

Inositol Trisphosphate Kinase and Diphosphoinositol Pentakisphosphate Kinase Enzymes Constitute the Inositol Pyrophosphate Synthesis Pathway in Plants

This paper identifies AtITPK enzymes as the missing components in the plant inositol pyrophosphate synthesis pathway and shows their subcellular localization and effects on InsP7 and InsP8 levels.

HIV-1 Env gp41 Transmembrane Domain Dynamics are Modulated by Lipid, Water, and Ion Interactions

This study uses molecular dynamics simulations to investigate how lipid, water, and ion interactions affect the dynamics of HIV-1 Env gp41 transmembrane domain.