Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion.
R. Ventrella, S. K. Kim, J. Sheridan, A. C. Grata, E. Bresteau, O. A. Hassan, E. E. Suva, P. Walentek, B. Mitchell
The paper identifies two distinct mechanisms for multiciliated cell extrusion in Xenopus embryos: Notch-driven basal extrusion and Piezo1-driven apical extrusion, with age-dependent regulation.
bioRxiv · Jan 12, 2023Cell Biology