Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
K. A. Jara, N. M. Loening, P. N. Reardon, Z. Yu, P. Woonnimani, C. Brooks, C. H. Vesely, E. J. Barbar
This study investigates how multivalent binding of dynein light chains regulates the interactions of dynein intermediate chain with dynactin and NudE, revealing autoinhibition caused by intramolecular interactions.
bioRxiv · Jun 5, 2022Biophysics