P. N. Reardon

RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid

This study identifies RNA structures and N domains responsible for specific interactions and phase separation in SARS-CoV-2 nucleocapsid, showing that multiple weak interactions drive phase separation while strong interactions are specific.

Modifications to the SR-Rich Region of the SARS-CoV-2 Nucleocapsid Regulate Self-Association and Attenuate RNA Interactions

This study identifies how modifications to the SARS-CoV-2 N nucleocapsid protein's SR-rich linker region affect self-association and RNA interactions through structural and biochemical analyses.

Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein

This study investigates how multivalent binding of dynein light chains regulates the interactions of dynein intermediate chain with dynactin and NudE, revealing autoinhibition caused by intramolecular interactions.

Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

The paper identifies a mutation in S100A9 that stabilizes a non-functional conformation, revealing an evolutionary constraint on stabilizing mutations.

Calcium Sensitive Allostery Regulates the PI(4,5)P2 Binding Site of the Dysferlin C2A Domain

The paper identifies how calcium binding affects the dynamics of the dysferlin C2A domain's phosphoinositide binding site, revealing a mechanism for calcium-dependent membrane targeting.

Cataract-associated deamidations on the surface of γS-crystallin increase protein unfolding and flexibility at distant regions

This study identifies deamidation sites in γS-crystallin that increase protein dynamics and flexibility in distant regions, contributing to cataract formation.