RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid
A. B. Estelle, H. M. Forsythe, Z. Yu, K. Hughes, B. Lasher, P. Allen, P. N. Reardon, D. A. Hendrix, E. J. Barbar
This study identifies RNA structures and N domains responsible for specific interactions and phase separation in SARS-CoV-2 nucleocapsid, showing that multiple weak interactions drive phase separation while strong interactions are specific.
bioRxiv · Jul 2, 2023Biophysics