P.-J. Corringer

Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome.

This study investigates two Kir2.1 mutants linked to Andersen-Tawil syndrome, showing they impair channel function through distinct mechanisms, with C154Y causing dominant-negative effects.

A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor α1

This study uses simulations to identify multiple cannabinoid-binding sites on zebrafish GlyR-1, validating predictions with experiments.

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

The paper uses fluorescence and simulations to reveal a progressive conformational change in the glycine receptor that precedes channel activation.

The desensitization pathway of GABAA receptors, one subunit at a time

The paper investigates the desensitization mechanism of GABAA receptors by introducing mutations one subunit at a time and finding synergistic effects and an asymmetric contribution of the γ2 subunit.

Mutational analysis to explore long-range allosteric coupling and decoupling in a pentameric channel receptor

The paper investigates long-range allosteric coupling and decoupling in a pentameric channel receptor using mutations, electrophysiology, fluorescence, and simulations.