R. Wagner

Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome.

This study investigates two Kir2.1 mutants linked to Andersen-Tawil syndrome, showing they impair channel function through distinct mechanisms, with C154Y causing dominant-negative effects.

Influenza A (N1-N9) and Influenza B (B/Vic and B/Yam) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine design

The paper develops NA pseudotype vectors and a pELLA assay to measure neuraminidase inhibition, showing improved sensitivity over existing methods for vaccine immunogenicity assessment.

A new twist in ABC transporter mediated multidrug resistance - Pdr5 is a drug/proton co-transporter

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

Establishment of pan-Influenza A (H1-H18) and pan-Influenza B (pre-split, Vic/Yam) Pseudotype Libraries for efficient vaccine antigen selection

The paper develops HA pseudotype libraries for Influenza A and B to improve vaccine antigen selection and neutralization assay capabilities.

Molecular architecture of black widow spider neurotoxins

This study reports cryoEM structures of two Latrotoxins (LaTXs) and proposes a cyclic oligomerization mechanism, revealing structural insights into their molecular action.

A pair of non-competing neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model

The paper identifies two clusters of non-competing neutralizing antibodies against SARS-CoV-2 that protect mice from infection and weight loss.

Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

The paper develops a multi-parameter formulation for an HIV vaccine protein, validating epitope binding and stoichiometry using advanced biophysical tools.

Immune response to vaccine candidates based on different types of nanoscaffolded RBD domain of the SARS-CoV-2 spike protein

This study evaluates DNA vaccines with RBD domains scaffolded by different peptides, finding that the β-annulus scaffold elicits the strongest immune response in mice.