Photoswitchable binders enable temporal dissection of endogenous protein function
M. Westberg, D. Song, V. Duong, D. Fernandez, P.-S. Huang, M. Z. Lin
This paper introduces photoswitchable DARPins (psDARPins) for optical control of endogenous protein function, demonstrating their use in inhibiting ERK and Ras and studying EGFR to ERK signaling.
bioRxiv · Sep 14, 2023 · PreprintBiochemistry