Disarrangement of Endoplasmic reticulum-mitochondria communication impairs Ca2+ homeostasis in FRDA
Laura R. Rodríguez, Pablo Calap-Quintana, Tamara Lapeña-Luzón, Federico Vicente Pallardó, Stephan Schneuwly, Juan A. Navarro, Pilar González‐Cabo
This study shows that frataxin deficiency disrupts ER-mitochondria communication, impairing calcium homeostasis in FRDA models, and that restoring mitochondrial calcium uptake can alleviate some defects.
bioRxiv · Mar 27, 2020 · PreprintNeuroscience