Laura R. Rodríguez

This study shows that Galectin-3 promotes tau pathology, neuroinflammation, white matter degeneration, and proteomic dysregulation, and that its deletion reduces these effects.

This study demonstrates that overexpressing OLIG2 and SOX10 in human astrocytes converts them into oligodendrocytes ex vivo, preserving brain architecture and showing potential for myelin repair in MS.

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.

This study shows that frataxin deficiency disrupts ER-mitochondria communication, impairing calcium homeostasis in FRDA models, and that restoring mitochondrial calcium uptake can alleviate some defects.