MicrobiologymBioPeer-reviewed
Carboxypeptidase activity drives L,D-transpeptidase essentiality during vegetative growth and sporulation in Clostridioides difficile
Kevin W. Bollinger, Ute Müh, Paige B Brannen…·Craig D. Ellermeier
This paper identifies DD-CPases as the source of tetrapeptides for LDTs in C. difficile and shows that LDTs are essential due to high DD-CPase activity, not for divisome/elongasome function.
DOI 10.1128/mbio.01580-26