A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
Neetu Srivastava, Anthony N. Vomund, Rongzhen Yu, Orion J. Peterson, Yuqing Yang, David P Turicek, Omar Abousaway, Tiandao Li, Lisa Kain, Pamela Stone, Aisha Ansar, Cristina Corina Clement, Siddhartha M. Sharma, Rima Melhem, Bo Zhang, , Xiaoxiao Wan
The paper identifies a microenvironment-driven neoantigen, C19S, in type 1 diabetes that activates persistent memory T cells through HLA-DQ8 recognition.
Nature Immunology · Nov 28, 2025Peer-reviewedImmunology