Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of Klebsiella pneumoniae
Kulsum Mehboob Dawoodbhoy, Coco R. Beudeker, Panagiotis Theofilidis, Frerich M. Masson, Michiel van der Flier, Suzan H. M. Rooijakkers, Bart W. Bardoel, Dennis J. Doorduijn
This study shows that excessive C5 conversion in Klebsiella pneumoniae strains limits C9 polymerisation, preventing MAC-dependent killing, but adding C9 restores killing, indicating these strains are not truly resistant.
PLoS Pathogens · May 11, 2026Peer-reviewedImmunology