Suzan H. M. Rooijakkers

This study shows that complement proteins like C1q block FcγR engagement with IgG, reducing their role in neutrophil phagocytosis, while complement receptors still enhance bacterial clearance.

This study identifies a C3b-specific nanobody that binds C3b but not C3, and inhibits the alternative pathway convertases of the complement system.

This study shows that MIB protein binds all human antibody isotypes, reduces Fab flexibility, and displaces antigens in immune complexes without affecting Fc interactions.

This study shows that excessive C5 conversion in Klebsiella pneumoniae strains limits C9 polymerisation, preventing MAC-dependent killing, but adding C9 restores killing, indicating these strains are not truly resistant.

The paper tracks MAC pore localization on E. coli and finds that MAC deposition starts at the new bacterial pole, leading to inner membrane damage and halting division.

This study tracks longitudinal changes in the plasma proteome and complexome of kidney failure patients before and after transplantation, revealing acute phase protein dynamics and macromolecular complex formation during inflammation.

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.