The lncRNA HOTAIR/EZH2 interaction inhibitor AC1Q3QWB (AQB) attenuates fibrotic SSc skin tissue re-modelling
Christopher W. Wasson, Panji Mulipa, Sophie L. Dibb, Esther Perez Barreiro, Rebecca L Ross, Francesco Del Galdo, Natalia A. Riobo‐Del Galdo
This paper shows that inhibiting the HOTAIR/EZH2 interaction with AQB reduces pro-fibrotic gene expression and tissue remodeling in SSc fibroblasts and skin.
bioRxiv · Jun 16, 2026 · PreprintCell Biology