TeTIR domains define a new class of animal TIR-like NADase effectors in STAND proteins
Joëlle Hornebeck, Ruslan Ibragimov, Nicole Oelerich, Paolo Pfad, Jan Jirschitzka, Jan M. Gebauer, Ulrich Baumann, Thomas Hermanns, Kay Hofmann
The paper identifies TeTIR domains as a new class of TIR-like NADase effectors in STAND proteins, showing NADase activity and structural features distinct from canonical TIR domains.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry