Kay Hofmann

Survey of the human proteostasis network: the ubiquitin-proteasome system

The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.

TeTIR domains define a new class of animal TIR-like NADase effectors in STAND proteins

The paper identifies TeTIR domains as a new class of TIR-like NADase effectors in STAND proteins, showing NADase activity and structural features distinct from canonical TIR domains.

Molecular basis for C-degron recognition by the SCFDas1 ubiquitin ligase

The paper investigates how the SCFDas1 ubiquitin ligase recognizes C-terminal degrons, identifying a conserved binding site and key residues involved in substrate recognition.

The importance of UBQLN2 ubiquitylation for its turnover and localization

This study shows that ubiquitylation of UBQLN2's UBL domain regulates its stability and localization, with implications for proteasomal degradation and ALS.

DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane

The paper identifies plant-specific DUC deubiquitinases that stabilize endocytic cargo at the plasma membrane by cleaving K63-linked ubiquitin chains.

Identification and characterization of a ubiquitin E3 RING ligase of the Chlamydia-like bacterium Simkania negevensis

This study characterizes a ubiquitin E3 RING ligase from Simkania negevensis, showing it generates K63- and K11-linked ubiquitin chains and interacts with specific E2 ligases.

PEX39 facilitates the peroxisomal import of PTS2 proteins

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

A family of bacterial Josephin-like deubiquitinases with an unusual cleavage mode

The paper identifies a new family of bacterial deubiquitinases that cleave ubiquitin before the C-terminal diGly motif, truncating the modifier and leaving a remnant on the substrate.