Thomas Hermanns

The paper identifies TeTIR domains as a new class of TIR-like NADase effectors in STAND proteins, showing NADase activity and structural features distinct from canonical TIR domains.

The paper identifies plant-specific DUC deubiquitinases that stabilize endocytic cargo at the plasma membrane by cleaving K63-linked ubiquitin chains.

This study characterizes a ubiquitin E3 RING ligase from Simkania negevensis, showing it generates K63- and K11-linked ubiquitin chains and interacts with specific E2 ligases.

The paper identifies a new family of bacterial deubiquitinases that cleave ubiquitin before the C-terminal diGly motif, truncating the modifier and leaving a remnant on the substrate.

The paper investigates how genomic alterations affect molecular networks in prostate cancer by integrating genomic, transcriptomic, and proteomic data from 105 samples, identifying a sub-network predictive of tumor aggressiveness and recurrence.

This study develops a deep learning model to automate Gleason grading of prostate cancer tissue microarrays, achieving agreement with pathologists and expert-level patient stratification.