Author

Jan Jirschitzka

University of CologneORCID 0000-0003-1007-4700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Bruno HüetteliD· 1 shared Federica LocciiD· 1 shared Henriette LaessleiD· 1 shared Jan M. GebaueriD· 1 shared Jane E. ParkeriD· 1 shared Jaqueline BautoriD· 1 shared Jingqi CheniD· 1 shared Joëlle Hornebeck· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPlant Biology

Bruno HüettelORCID

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2 papers

Recent·Most cited

TeTIR domains define a new class of animal TIR-like NADase effectors in STAND proteins

Joëlle Hornebeck, Ruslan Ibragimov, Nicole Oelerich, Paolo Pfad, Jan Jirschitzka, Jan M. Gebauer, Ulrich Baumann, Thomas Hermanns, Kay Hofmann

The paper identifies TeTIR domains as a new class of TIR-like NADase effectors in STAND proteins, showing NADase activity and structural features distinct from canonical TIR domains.

bioRxiv · Sep 22, 2026 · PreprintBiochemistry

Conserved TIR-only proteins drive transcriptional defense and basal immunity in dicot and monocot plants

Henriette Laessle, Oliver Johanndrees, Jingqi Chen, Sabine Haigis, 이탁, Y M Chen, Li Liu, Wen Song, Jaqueline Bautor, Jan Jirschitzka, Bruno Hüettel, Li Wan, Federica Locci, Jane E. Parker

This study identifies conserved TIR-only proteins in dicots and monocots that promote basal immunity and transcriptional defense independently of NLR pathways.

bioRxiv · Jun 8, 2026 · PreprintPlant Biology