The mechanical anisotropy of adipose tissues regulates ovarian cancer invasion
Jordi Gonzalez‐Molina, Parisa Nabili, Daniele Marciano, Sara Abdelnabi, Okan Gultekin, Mohammed Fatih Rasul, Yikun Zhang, Clémence Nadal, Alexandra Chrysanthou, Twana Alkasalias, Sahar Salehi, Frances R. Balkwill, Kaisa Lehti, Julien E. Gautrot
This study shows that mechanical anisotropy in adipose tissues influences ovarian cancer cell migration through TGFβ-dependent mechanisms, independent of MMP activity.
Nature Communications · Sep 29, 2025Peer-reviewedBioengineering