Frances R. Balkwill

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinomaprecursors

This study reconstructs transcriptional trajectories of Fallopian-tube epithelium to show STICs occupy diverse positions along a progression continuum and exhibit variable PARPi resistance signatures.

Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer

The paper shows that modifying the tumor microenvironment's extracellular matrix improves chemotherapy response in ovarian cancer models.

The mechanical anisotropy of adipose tissues regulates ovarian cancer invasion

This study shows that mechanical anisotropy in adipose tissues influences ovarian cancer cell migration through TGFβ-dependent mechanisms, independent of MMP activity.