The Mycobacterium tuberculosis ESX-5 secretion system enables carbon source utilization and growth in mice
Alisha M. Block, Rashmi Ravindran Nair, Virginia Meikle, Parker C. Wiegert, Dylan W. White, Leanne Zhang, Michael Niederweis, Anna D. Tischler
This study shows that the M. tuberculosis ESX-5 secretion system is critical for growth on specific carbon sources, survival in macrophages, and replication in mice, suggesting it is a key virulence factor.
mBio · Jan 30, 2026Peer-reviewedMicrobiology