Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function
Kaylee D. Tutrow, Jade Harkin, L. Varghese, Melody Hernandez, Kang-Chieh Huang, Yue Fang, Parker Wilcox, Logan M. Bedford, Tsai‐Yu Lin, Chi Zhang, Cátia Gomes, Shweta S. Puntambekar, Stephanie J. Bissel, Bruce T. Lamb, Jason S. Meyer
This study shows that the CX3CR1-V249I variant in human microglia leads to dysfunctional phenotypes and affects neuronal growth and function.
bioRxiv · Jul 1, 2025 · PreprintNeuroscience