Author

Tsai‐Yu Lin

Indiana University IndianapolisORCID 0000-0002-8076-1584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Bruce T. LambiD· 1 shared Cátia GomesiD· 1 shared Chi ZhangiD· 1 shared Christian BrendeliD· 1 shared Danilo PelliniD· 1 shared Denise KlattiD· 1 shared Giacomo CeoldoiD· 1 shared Jade HarkiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Bruce T. LambORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Modeling integration site data for safety assessment with MELISSA

Tsai‐Yu Lin, Giacomo Ceoldo, Kimberley D. House, M. Welty, Thao Thi Dang, Denise Klatt, Christian Brendel, Michael P. Murphy, Kenneth G. Cornetta, Danilo Pellin

MELISSA assesses insertional mutagenesis risk by analyzing integration site data, identifying over- and under-targeted genes and their impact on clone fitness.

Nature Communications · Aug 23, 2025Peer-reviewedBioinformatics

Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function

Kaylee D. Tutrow, Jade Harkin, L. Varghese, Melody Hernandez, Kang-Chieh Huang, Yue Fang, Parker Wilcox, Logan M. Bedford, Tsai‐Yu Lin, Chi Zhang, Cátia Gomes, Shweta S. Puntambekar, Stephanie J. Bissel, Bruce T. Lamb, Jason S. Meyer

This study shows that the CX3CR1-V249I variant in human microglia leads to dysfunctional phenotypes and affects neuronal growth and function.

bioRxiv · Jul 1, 2025 · PreprintNeuroscience