Kang-Chieh Huang

This study uses a human pluripotent stem cell tri-culture system to investigate how microglia influence retinal ganglion cell health and disease in neuroinflammation.

This study uses microfluidic platforms to model human retinal ganglion cell compartmentalization, showing axonal deficits in disease and astrocyte reactivity-induced neurodegeneration.

This study shows that the CX3CR1-V249I variant in human microglia leads to dysfunctional phenotypes and affects neuronal growth and function.

This paper develops an in vitro model to study human retinal ganglion cell (RGC) connectivity with specific brain regions, showing that cultured RGCs form region-specific synapses with mouse brain targets.

This study shows that autophagy disruption reduces mTORC1 activation, leading to retinal ganglion cell degeneration in glaucoma, and identifies potential therapeutic targets.

The paper identifies that enhancing mitochondrial biogenesis through TBK1 inhibition protects glaucomatous retinal ganglion cells from mitochondrial damage.

This study shows that hPSC-derived RGCs with the OPTN(E50K) mutation display neurodegenerative phenotypes, providing insights into glaucoma mechanisms.