Stephanie J. Bissel

This study shows that the CX3CR1-V249I variant in human microglia leads to dysfunctional phenotypes and affects neuronal growth and function.

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

The paper identifies a rare PLCG2 variant that increases Alzheimer's disease risk and shows increased PLCG2 expression correlates with amyloid deposition in AD patients.