PNPLA3 I148M Reduces Hepatic Triacylglycerol Secretion and Mitigates Left Ventricular Diastolic Dysfunction in MASH Diet Mice
Andrew J. Butcko, Parsa Kamali, Nivedita Tiwari, Abir A. Rahman, Grace Teskey, Kehinde Ahmad Adeshina, Nikhlesh Kumar Singh, James G. Granneman, Emilio P. Mottillo
This study shows that PNPLA3-I148M reduces hepatic TAG secretion and protects against cardiac diastolic dysfunction in MASH diet mice, despite promoting liver steatosis.
bioRxiv · Apr 24, 2025 · PreprintPhysiology