James G. Granneman

This study investigates how ABHD5 partitions between ER bilayers and LD monolayers using model membranes and computational modeling, revealing biophysical factors that drive its membrane selectivity.

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

This study identifies a dual-site membrane recognition mechanism in ABHD5 that enables its activation and regulation of lipid metabolism.

This study shows that PNPLA3-I148M reduces hepatic TAG secretion and protects against cardiac diastolic dysfunction in MASH diet mice, despite promoting liver steatosis.

This study shows that LD targeting of ABHD5 and PNPLA3 I148M is necessary for their interaction and promotes liver steatosis.