Emilio P. Mottillo

Multiscale Analysis of PNPLA2 and PNPLA3 Membrane Targeting

This study investigates how PNPLA2 and PNPLA3 bind to ER and LD membranes using simulations and microscopy, revealing distinct binding modes and their impact on catalytic activity.

PNPLA3 I148M Reduces Hepatic Triacylglycerol Secretion and Mitigates Left Ventricular Diastolic Dysfunction in MASH Diet Mice

This study shows that PNPLA3-I148M reduces hepatic TAG secretion and protects against cardiac diastolic dysfunction in MASH diet mice, despite promoting liver steatosis.

Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis

This study shows that LD targeting of ABHD5 and PNPLA3 I148M is necessary for their interaction and promotes liver steatosis.