Author

Patrick D. Wilson

University at Buffalo, State University of New York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Michael Joseph BuckiD· 3 shared Christopher R. HandelmanniD· 2 shared Maria TsompanaiD· 1 shared Vijaya Murugaiyan· 1 shared Xinyang YuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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3 shared papersMolecular Biology

Michael Joseph BuckORCID

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3 papers

Recent·Most cited

Cooperative FOXA1-HNF4A binding emerges from motif spacing and nucleosome architecture

Patrick D. Wilson, Michael Joseph Buck

The paper identifies sequence and chromatin features that enable cooperative binding between FOXA1 and HNF4A, showing that motif spacing and nucleosome architecture are key factors.

bioRxiv · May 30, 2026 · PreprintGenomics

Defining transcription factor nucleosome binding with Pioneer-seq

Maria Tsompana, Patrick D. Wilson, Vijaya Murugaiyan, Christopher R. Handelmann, Michael Joseph Buck

This study introduces Pioneer-seq to analyze TF nucleosome binding and finds that KLF4 and SOX2 bind near the nucleosome dyad, with nucleosome sequence being the major determinant of TF binding.

PLoS Genetics · Aug 14, 2025Peer-reviewedMolecular Biology

Nucleosome-binding by TP53, TP63, and TP73 is determined by the composition, accessibility, and helical orientation of their binding sites

Patrick D. Wilson, Xinyang Yu, Christopher R. Handelmann, Michael Joseph Buck

This study examines how TP53, TP63, and TP73 bind to nucleosomes by analyzing binding site accessibility, composition, and helical orientation using Pioneer-seq.

bioRxiv · May 3, 2024Molecular Biology