Michael Joseph Buck

The paper maps subgingival microbiome states in 1,355 adults, identifying divergent dysbiosis trajectories linked to periodontitis and host factors.

The paper identifies sequence and chromatin features that enable cooperative binding between FOXA1 and HNF4A, showing that motif spacing and nucleosome architecture are key factors.

This study introduces Pioneer-seq to analyze TF nucleosome binding and finds that KLF4 and SOX2 bind near the nucleosome dyad, with nucleosome sequence being the major determinant of TF binding.

This study examines how TP53, TP63, and TP73 bind to nucleosomes by analyzing binding site accessibility, composition, and helical orientation using Pioneer-seq.

The paper shows that Lola-I, a Drosophila zinc finger transcription factor, regulates promoter accessibility and paused Pol II during development, similar to enhancer regulation by pioneer factors.

The paper develops a targeted sequencing approach to analyze mutation profiles in yeast and identifies genotype-specific variants influenced by dNTP pool changes.

This study investigates p53's ability to bind nucleosomal DNA through competitive binding assays, showing it binds primarily at nucleosome edges with non-specific binding facilitating its pioneering function.

This study demonstrates the feasibility of creating multi-dimensional genomic maps for juvenile idiopathic arthritis using limited patient samples and identifies epigenetic and genetic features associated with the disease.