Defining transcription factor nucleosome binding with Pioneer-seq
Maria Tsompana, Patrick D. Wilson, Vijaya Murugaiyan, Christopher R. Handelmann, Michael Joseph Buck
This study introduces Pioneer-seq to analyze TF nucleosome binding and finds that KLF4 and SOX2 bind near the nucleosome dyad, with nucleosome sequence being the major determinant of TF binding.
PLoS Genetics · Aug 14, 2025Peer-reviewedMolecular Biology