Mirror-image mRNA display uncovers isoform-selective D-peptide macrocycles targeting a cryptic KRAS pocket
Matthew J. Mitcheltree, Nicole Boo, Nicolas C. Boyer, Zachary Z. Brown, Xiaomei Chai, Ruchia Duggal, Michael Garrigou, Robert P. Hayes, Jennifer M. Johnston, Hubert B. Josien, Brian M. Lacey, Shuhui Lim, Songnian Lin, Mayhood Todd, Haruhiko Ogawa, , Kaustav Biswas
This paper uses mirror-image mRNA display to discover D-peptide macrocycles targeting a new KRAS binding site, showing selectivity and efficacy in inhibiting KRAS-mutant cells.
bioRxiv · May 22, 2026 · PreprintCancer Biology