CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis
Lucía Valenzuela-Pérez, Hyun Se Kim Lee, Rachel L. Bayer, Dina Faeq Manna, Shravan K. Mishra, Alexander M. Washington, AbidM Hassan, Malaz M. Sidahmed, Edward Ssali, Ece Janet Dinç, Benie K. Manwana, Ahmed Ibrahim, Qianqian Guo, Adam Herman, Rondell P. Graham, , Petra Hirsova
This study identifies CD4+ T cells as drivers of fibrosis in MASH by showing their proinflammatory activity and the therapeutic potential of targeting the OX40L-OX40 axis.
Hepatology · Apr 30, 2026Peer-reviewedImmunology