Author

Lucía Valenzuela-Pérez

Mayo ClinicORCID 0000-0002-5145-303XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adebowale O. BamideleiD· 2 shared Hyun Se Kim LeeiD· 2 shared Petra HirsovaiD· 2 shared AbidM Hassan· 1 shared Adam HermaniD· 1 shared Ahmed Ibrahim· 1 shared Alexander M. WashingtoniD· 1 shared Benie K. Manwana· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Adebowale O. BamideleORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis

Lucía Valenzuela-Pérez, Hyun Se Kim Lee, Rachel L. Bayer, Dina Faeq Manna, Shravan K. Mishra, Alexander M. Washington, AbidM Hassan, Malaz M. Sidahmed, Edward Ssali, Ece Janet Dinç, Benie K. Manwana, Ahmed Ibrahim, Qianqian Guo, Adam Herman, Rondell P. Graham, , Petra Hirsova

This study identifies CD4+ T cells as drivers of fibrosis in MASH by showing their proinflammatory activity and the therapeutic potential of targeting the OX40L-OX40 axis.

Hepatology · Apr 30, 2026Peer-reviewedImmunology

Metabolic Reprogramming of Pathogenic CD4+ T Helper Cells Attenuates Inflammatory Bowel Disease Pathogenesis

Shravan Kumar Mishra, Leena M. Abdelrahman, Heidi M. Davidson, Hyun Se Kim Lee, Lucía Valenzuela-Pérez, Omar Mohamed Hassan, William A. Faubion, Petra Hirsova, Adebowale O. Bamidele

This study shows that metabolic reprogramming of Th1 cells via GSK3β inhibition reduces inflammation in IBD by suppressing glycolysis and cytokine production.

bioRxiv · Apr 15, 2025 · PreprintImmunology